IL-21/IL-21R in Autoimmune Diseases
نویسندگان
چکیده
Interleukin-21 (IL-21), the member of the γ-chain-related cytokine family, and its receptor (IL-21R), has been evidenced involving in the immune response, resulting in the development of autoimmune diseases, infectious diseases and tumors. This short communication reviews an overall outline of its genetic variants and expression in autoimmune diseases. It focuses on a series of recent studies that have supporting the pathogenic role through human or animal experiments in vitro or in vivo.
منابع مشابه
Upregulated IL-21 and IL-21 receptor expression is involved in experimental autoimmune uveitis (EAU)
PURPOSE Interleukin (IL)-21 has recently been shown to play a vital role in the development of many autoimmune diseases. Our study is designed to investigate the alteration and possible function of IL-21 in the development of an experimental autoimmune uveitis (EAU) model. METHODS EAU was induced in B10.RIII mice by subcutaneous injection of interphotoreceptor retinoid-binding protein (IRBP) ...
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